Overview
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
USERS' SCORE
Good
Based on 5 Reviews
8.4
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folic Acid
400 mcg
100%
Vitamin B-12 (as Cyanocobalamin)
5 mg (5,000 mcg)
83,333%
Top Medical Research Studies
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
Read More
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
We examined the link between folic acid and vitamin B12 levels and high blood pressure in children and adolescents. Using a nested case-control and cohort study design, we found that those with elevated blood pressure had lower levels of these vitamins compared to control groups. Notably, low folic acid levels were associated with higher blood pressure readings and an imbalance in lipid levels. Our findings highlight the importance of ensuring adequate intake of folic acid and vitamin B12 in childhood, either through diet or supplements, to help regulate blood pressure.
Read More
Most Useful Reviews
7.5
Supports cardiovascular health
5 people found this helpful
Vitamin B12 lowers levels of homocysteine, which raises the risk of heart attacks or strokes. In combating cardiovascular disease, vitamin B12 must partner with folic acid. Additionally, it plays a role in choline production, helping to counter poor dietary habits and prevent fatty liver degeneration. Moreover, B12 is vital for synthesising amino acids, which positively influences mental activity and emotional wellbeing.
Read More
9
Eliminated numbness
3 people found this helpful
I got rid of my left hand numbness! After being diagnosed with OPLL last February and failing to respond to medication, I found this supplement online. Remarkably, the numbness faded away on the second day of taking it. I've been using it daily since then, with no side effects. It’s truly the best match for me.
Read More
9
Supports cardiovascular health
Vitamin B12 (cyanocobalamin) is a water-soluble vitamin vital for a healthy nervous system and for converting fat and protein into energy. It's also crucial for DNA synthesis during cell division, particularly for rapidly dividing cells like blood cells. Sufficient intake of B12, along with folic acid and vitamin B6, is essential for converting homocysteine to methionine, thereby supporting cardiovascular health. Since B12 is mainly sourced from animal products, supplements may be significant for strict vegetarians.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 9 Researches
6.7
- All Researches
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
Read More
8
We investigated how exposure to metal mixtures during pregnancy influences blood pressure and hypertension later in life.
Using data from Project Viva, we followed 493 women over an average of 18 years.
Our findings revealed that higher levels of vitamin B12, along with essential metals like copper and manganese, were linked to lower blood pressure and reduced hypertension risk.
However, some metals showed mixed results, indicating a complex relationship.
Overall, optimizing nutrient levels during pregnancy may offer lasting benefits for women's cardiovascular health.
Using data from Project Viva, we followed 493 women over an average of 18 years.
Our findings revealed that higher levels of vitamin B12, along with essential metals like copper and manganese, were linked to lower blood pressure and reduced hypertension risk.
However, some metals showed mixed results, indicating a complex relationship.
Overall, optimizing nutrient levels during pregnancy may offer lasting benefits for women's cardiovascular health.
Read More
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Read More
7
We examined a unique case involving a 57-year-old man who experienced a myocardial infarction due to coronary artery spasm. His condition was associated with high serum homocysteine levels and low vitamin B12. Following treatment with vitamin B12 and calcium channel antagonists, his homocysteine levels normalized, and he reported no further chest pain or spasm.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
Read More
7
We investigated how blood levels of B vitamins, particularly B6 and B12, influence blood pressure variability (BPV) in individuals with essential hypertension.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports cardiovascular health
5 people found this helpful
Vitamin B12 lowers levels of homocysteine, which raises the risk of heart attacks or strokes. In combating cardiovascular disease, vitamin B12 must partner with folic acid. Additionally, it plays a role in choline production, helping to counter poor dietary habits and prevent fatty liver degeneration. Moreover, B12 is vital for synthesising amino acids, which positively influences mental activity and emotional wellbeing.
Read More
9
Eliminated numbness
3 people found this helpful
I got rid of my left hand numbness! After being diagnosed with OPLL last February and failing to respond to medication, I found this supplement online. Remarkably, the numbness faded away on the second day of taking it. I've been using it daily since then, with no side effects. It’s truly the best match for me.
Read More
9
Supports cardiovascular health
Vitamin B12 (cyanocobalamin) is a water-soluble vitamin vital for a healthy nervous system and for converting fat and protein into energy. It's also crucial for DNA synthesis during cell division, particularly for rapidly dividing cells like blood cells. Sufficient intake of B12, along with folic acid and vitamin B6, is essential for converting homocysteine to methionine, thereby supporting cardiovascular health. Since B12 is mainly sourced from animal products, supplements may be significant for strict vegetarians.
Read More
9
Excellent quality
The quality, taste, ingredients, and benefits of this vegetarian nutritional supplement are excellent. B-12 is necessary for maintaining a healthy nervous system and for producing energy from fats and proteins. It supports DNA synthesis during cell division, which is essential for rapidly multiplying cells like blood cells. Furthermore, sufficient B-12, alongside folic acid and vitamin B-6, is crucial for converting homocysteine to methionine, thereby promoting cardiovascular health.
Read More
7.5
Supports cardiovascular system
It supports my healthy cardiovascular system and is easy to swallow.
Read More
Frequently Asked Questions
9
Eliminated numbness
3 people found this helpful
I got rid of my left hand numbness! After being diagnosed with OPLL last February and failing to respond to medication, I found this supplement online. Remarkably, the numbness faded away on the second day of taking it. I've been using it daily since then, with no side effects. It’s truly the best match for me.
9
Excellent quality
The quality, taste, ingredients, and benefits of this vegetarian nutritional supplement are excellent. B-12 is necessary for maintaining a healthy nervous system and for producing energy from fats and proteins. It supports DNA synthesis during cell division, which is essential for rapidly multiplying cells like blood cells. Furthermore, sufficient B-12, alongside folic acid and vitamin B-6, is crucial for converting homocysteine to methionine, thereby promoting cardiovascular health.
9
Supports cardiovascular health
Vitamin B12 (cyanocobalamin) is a water-soluble vitamin vital for a healthy nervous system and for converting fat and protein into energy. It's also crucial for DNA synthesis during cell division, particularly for rapidly dividing cells like blood cells. Sufficient intake of B12, along with folic acid and vitamin B6, is essential for converting homocysteine to methionine, thereby supporting cardiovascular health. Since B12 is mainly sourced from animal products, supplements may be significant for strict vegetarians.
7.5
Supports cardiovascular health
5 people found this helpful
Vitamin B12 lowers levels of homocysteine, which raises the risk of heart attacks or strokes. In combating cardiovascular disease, vitamin B12 must partner with folic acid. Additionally, it plays a role in choline production, helping to counter poor dietary habits and prevent fatty liver degeneration. Moreover, B12 is vital for synthesising amino acids, which positively influences mental activity and emotional wellbeing.
7.5
Supports cardiovascular system
It supports my healthy cardiovascular system and is easy to swallow.
8
We examined the role of vitamin B status on mortality rates, focusing on cardiovascular disease. Using data from over 12,000 adults, we found that higher scores on the combined vitamin B status indicator (3cB) were linked to lower risks of dying from cardiovascular issues. Specifically, individuals with lower 3cB scores faced significantly higher risks of mortality. This suggests that maintaining adequate vitamin B levels could potentially play an important part in reducing cardiovascular disease-related deaths.
7
We examined a unique case involving a 57-year-old man who experienced a myocardial infarction due to coronary artery spasm. His condition was associated with high serum homocysteine levels and low vitamin B12. Following treatment with vitamin B12 and calcium channel antagonists, his homocysteine levels normalized, and he reported no further chest pain or spasm.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
This case suggests that managing homocysteine levels might be an effective strategy in preventing coronary artery spasm, highlighting vitamin B12's potential role in cardiovascular health.
7
We investigated how blood levels of B vitamins, particularly B6 and B12, influence blood pressure variability (BPV) in individuals with essential hypertension.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
Our study included 100 patients with hypertension and 100 healthy controls. We discovered that both B vitamin levels were notably lower in the hypertensive group, while their BPV indices were significantly higher.
Interestingly, those with higher levels of B vitamins showed reduced BPV, suggesting that boosting these vitamins might help manage hypertension. However, while the trend is promising, it doesn't establish a definitive cause-and-effect relationship.
8
Vitamin B12 reduces cardiovascular risks
We explored the connection between vitamin B12, genetic factors, and cardiovascular health in a group of Chinese adults suffering from hypertension. By analyzing the genetic variations of individuals, we aimed to understand how these may influence levels of homocysteine, an amino acid that can impact heart health when present in high amounts.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
Our study included 1,304 participants over the age of 18. We measured their serum levels of vitamin B12 and folate, as well as their total homocysteine concentrations. The findings were quite significant: adequate levels of both vitamin B12 and folate were linked to lower homocysteine levels. This suggests that ensuring proper nutrition might be key to managing cardiovascular risks associated with high homocysteine.
We also noticed that the genotypic effects on homocysteine levels could be lessened with sufficient intake of these vitamins. Targeted nutritional interventions, such as increasing vitamin B12 and folate in the diet, could therefore play an essential role in heart health for those at risk. Our results emphasize the importance of nutrition in supporting cardiovascular health and managing hypertension.
References
- Li Y, Wang H, Chen S, Wei Q, Liu Y, et al. The combined indicator of vitamin B status calculated using 3-parameters (3cB) is negatively associated with mortality among US adults: NHANES 1999 to 2004. Nutr Res. 2025;136:53. doi:10.1016/j.nutres.2025.02.008
- Ikeda A, Akama J, Ohki Y, Kunii H, Saitoh SI. Myocardial infarction with non-obstructive coronary artery caused by coronary artery spasm and an increase in serum homocysteine: a case report. Eur Heart J Case Rep. 2025;9:ytaf118. doi:10.1093/ehjcr/ytaf118
- Bian XY, Cui C, Zhang QY. Relationship between blood pressure variability and vitamin B level in essential hypertension. J Physiol Pharmacol. 2025;76. doi:10.26402/jpp.2025.1.02
- Zhang M, Aris IM, Cardenas A, Rifas-Shiman SL, Lin PD, et al. Pregnancy Metal Mixtures and Blood Pressure and Hypertension in Mid-Life: A Prospective U.S. Cohort Study. Hypertension. 2025. doi:10.1161/HYPERTENSIONAHA.124.23980
- Chen X, Bishai D. Revisiting cost-effectiveness of folic acid supplementation in primary stroke prevention in China: considering vitamin B12 deficiency masking issue. BMC Public Health. 2024;24:3540. doi:10.1186/s12889-024-21005-7
- Chen B, Wang C, Li W. Genetic insights into the effect of trace elements on cardiovascular diseases: multi-omics Mendelian randomization combined with linkage disequilibrium score regression analysis. Front Immunol. 2024;15:1459465. doi:10.3389/fimmu.2024.1459465
- Liang X, Huang D, Bi Y, He Y, Mao T, et al. The impact of folic acid/VB12 deficiency on essential hypertension in children and adolescents: from a nested case-control and a cohort study. J Hum Hypertens. 2024;38:844. doi:10.1038/s41371-024-00955-w
- Jung E, Kook HY, Ryu SJ, Ryu HH, Kim HG. The Association of Vitamin B-12 Plasma Concentration with Stroke Incidence According to Sex. J Nutr. 2024;154:3012. doi:10.1016/j.tjnut.2024.08.002
- Siddiqi SM, Liu L, Du Y, Song Y, Chen P, et al. Association of MTHFR C677T, MTHFRA1298C, and MTRRA66G Gene Polymorphisms with Hyperhomocysteinemia and Its Modulation by the Combined Effect of Vitamin B12 and Folate in Chinese Population with Hypertension. J Nutr. 2024. doi:10.1016/j.tjnut.2024.09.003
